Detalhe da pesquisa
1.
SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801.
Nature
; 591(7850): 451-457, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33561864
2.
Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine.
J Virol
; 98(4): e0013224, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511932
3.
4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses.
PLoS Pathog
; 19(4): e1011342, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37068076
4.
ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32540975
5.
Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767721
6.
Small-Molecule Antiviral ß-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.
J Virol
; 93(24)2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578288
7.
ß-d-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.
J Virol
; 92(3)2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29167335
8.
Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5'-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180528
9.
Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29891600
10.
Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays.
Antimicrob Agents Chemother
; 61(3)2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27993851
11.
4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo.
mBio
; : e0042024, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38700353
12.
Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets.
Nat Commun
; 15(1): 1189, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38331906
13.
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection.
Antiviral Res
; 209: 105453, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36379378
14.
A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis.
ACS Med Chem Lett
; 14(10): 1338-1343, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849531
15.
Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models.
Nat Commun
; 14(1): 4731, 2023 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37550333
16.
Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 Mpro Inhibitors.
ACS Med Chem Lett
; 14(10): 1434-1440, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849558
17.
Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets.
bioRxiv
; 2022 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36451893
18.
4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication.
Science
; 375(6577): 161-167, 2022 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34855509
19.
4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication.
bioRxiv
; 2021 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34031658
20.
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase.
Nat Microbiol
; 5(10): 1232-1246, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32661315